Lane 1: Hela
Lane 2: Human lung
Lane 3: 293T
Lane 4: A549
Recombinant Rabbit monoclonal primary
ERCC1 Recombinant Rabbit Monoclonal Antibody [JM10-07] (ET1703-19)
A549, 293T, Hela, HepG2, PANC-1, human kidney tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
COFS 4 antibody; COFS4 antibody; DNA excision repair protein ERCC 1 antibody; DNA excision repair protein ERCC-1 antibody; DNA excision repair protein ERCC1 antibody; ERCC 1 antibody; ERCC1 antibody; ERCC1_HUMAN antibody; Excision repair cross complementation group 1 antibody; Excision repair cross complementing 1 antibody; Excision Repair Cross Complementing Rodent Repair Deficiency Complementation Group 1 antibody; Excision repair protein antibody; RAD 10 antibody; RAD10 antibody; UV 20 antibody; UV20 antibody
Belongs to the ERCC1/RAD10/SWI10 family.
Xeroderma pigmentosum (XP) is an autosomal recessive disorder characterized by a genetic predisposition to sunlight-induced skin cancer; it is commonly due to deficiencies in DNA repair enzymes. The most frequent mutations are found in the XP genes from group A through G and group V, which encode for nucleotide excision repair proteins. XPF, which is also designated ERCC4 or ERCC11, associates directly with the excision repair cross-complementing 1 (ERCC1) factor. ERCC-1, a functional homolog of Rad10 in S. cerevisiae, is a component of a structure-specific endonuclease that is responsible for 5' incisions during DNA repair. The ERCC1-XPF endo-nuclease preferentially cleaves one strand of DNA between duplex and single-stranded regions near borders of the stem-loop structure and, thereby, contributes to the initial steps of the nucleotide excision repair process.