ErbB4 Recombinant Rabbit Monoclonal Antibody [JE59-43] (HA721720)

UNIPROT #

Q15303

PROTEIN NAME

ErbB4

SYNONYMS

4ICD antibody;ALS19 antibody;Avian erythroblastic leukemia viral oncogene homolog 4 antibody;Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4 antibody;E4ICD antibody;EC 2.7.10.1 antibody;ErbB 4 antibody;Erbb4 antibody;ERBB4 intracellular domain antibody;ERBB4_HUMAN antibody;HER 4 antibody;HER4 antibody;human epidermal growth factor receptor 4 antibody;Mer4 antibody;MGC138404 antibody;Oncogene ERBB4 antibody;p180erbB4 antibody;Proto-oncogene-like protein c-ErbB-4 antibody;Receptor protein tyrosine kinase erbB 4 precursor antibody;Receptor tyrosine protein kinase erbB 4 antibody;s80HER4 antibody;Tyrosine kinase type cell surface receptor HER4 antibody;Tyrosine kinase-type cell surface receptor HER4 antibody;v erb a avian erythroblastic leukemia viral oncogene homolog like 4 antibody;v erb a erythroblastic leukemia viral oncogene homolog 4 antibody;v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) antibody;V-ERB-B2 avian erythroblastic leukemia viral oncogene homolog 4 antibody;Verba avian erythroblastic leukemia viral oncogene homolog like 4 antibody;Verba erythroblastic leukemia viral oncogene homolog 4 antibody;VERBB2 antibody

SUBCELLULAR LOCATION

Cell membrane; Nucleus, Mitochondrion.

FUNCTION

This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.