ERAB Rabbit Polyclonal Antibody (HA500150)

UNIPROT #

Q99714

PROTEIN NAME

ERAB

SYNONYMS

17 beta hydroxysteroid dehydrogenase 10 antibody;17 beta hydroxysteroid dehydrogenase type 10 antibody;17-beta-HSD 10 antibody;17-beta-hydroxysteroid dehydrogenase 10 antibody;17b HSD10 antibody;3 hydroxy 2 methylbutyryl CoA dehydrogenase antibody;3 hydroxyacyl CoA dehydrogenase type 2 antibody;3 hydroxyacyl CoA dehydrogenase type II antibody;3-hydroxy-2-methylbutyryl-CoA dehydrogenase antibody;3-hydroxyacyl-CoA dehydrogenase type II antibody;3-hydroxyacyl-CoA dehydrogenase type-2 antibody;AB binding alcohol dehydrogenase antibody;ABAD antibody;Ads9 antibody;Amyloid beta binding polypeptide antibody;Amyloid beta peptide binding alcohol dehydrogenase antibody;Amyloid beta peptide binding protein antibody;Amyloid beta peptide binding protein antibody;CAMR antibody;DUPXp11.22 antibody;Endoplasmic Reticulum Amyloid Binding Protein antibody;Endoplasmic reticulum associated amyloid beta peptide binding protein antibody;Endoplasmic reticulum-associated amyloid beta-peptide-binding protein antibody;ER associated amyloid beta-binding protein antibody;ERAB antibody;HADH 2 antibody;HADH2 antibody;HCD 2 antibody;HCD2 antibody;HCD2_HUMAN antibody;Hsd17b10 antibody;Hydroxyacyl CoA Dehydrogenase type II antibody;Hydroxyacyl Coenzyme A dehydrogenase type II antibody;Hydroxysteroid (17 beta) dehydrogenase 10 antibody;Mental retardation X linked syndromic 11 antibody;MHBD antibody;Mitochondrial L3 Hydroxyacyl CoA Dehydrogenase antibody;Mitochondrial ribonuclease P protein 2 antibody;Mitochondrial RNase P protein 2 antibody;MRPP2 antibody;MRX17 antibody;SCHAD antibody;SDR5C1 antibody;Short chain dehydrogenase/reductase family 5C member 1 antibody;Short chain L 3 hydroxyacyl CoA dehydrogenase type 2 antibody;Short chain type dehydrogenase/reductase XH98G2 antibody;Short-chain type dehydrogenase/reductase XH98G2 antibody;Type 10 17b HSD antibody;Type 10 17beta hydroxysteroid dehydrogenase antibody;Type II HADH antibody;XH98G2 antibody

SUBCELLULAR LOCATION

Mitochondrion.

FUNCTION

In addition to mitochondrial dehydrogenase activity, moonlights as a component of mitochondrial ribonuclease P, a complex that cleaves tRNA molecules in their 5'-ends . Together with TRMT10C/MRPP1, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity . The MRPP1-MRPP2 subcomplex catalyzes the formation of N1-methylguanine and N1-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; HSD17B10/MRPP2 acting as a non-catalytic subunit . The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme . Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly.