EPO-R Rabbit Polyclonal Antibody (HA500529)

UNIPROT #

P19235

PROTEIN NAME

EPO-R

SYNONYMS

EPO R antibody;EPO Receptor antibody;EPO-R antibody;epor antibody;EPOR_HUMAN antibody;Erythropoietin receptor antibody;Erythropoietin receptor precursor antibody;MGC138358 antibody

SUBCELLULAR LOCATION

Cell membrane; Secreted.

FUNCTION

The erythropoietin receptor (EpoR) is a protein that in humans is encoded by the EPOR gene. EpoR is a 52kDa peptide with a single carbohydrate chain resulting in an approximately 56-57 kDa protein found on the surface of EPO responding cells. It is a member of the cytokine receptor family. EpoR pre-exists as dimers. These dimers were originally thought to be formed by extracellular domain interactions, however, it is now assumed that it is formed by interactions of the transmembrane domain and that the original structure of the extracellular interaction site was due to crystallisation conditions and does not depict the native conformation. Binding of a 30 kDa ligand erythropoietin (Epo), changes the receptor's conformational change, resulting in the autophosphorylation of Jak2 kinases that are pre-associated with the receptor (i.e., EpoR does not possess intrinsic kinase activity and depends on Jak2 activity). At present, the most well-established function of EpoR is to promote proliferation and rescue of erythroid (red blood cell) progenitors from apoptosis.