Ephrin-A1 Mouse Monoclonal Antibody [A7B10] (HA601038)

UNIPROT #

P20827

PROTEIN NAME

Ephrin-A1

SYNONYMS

B61 antibody;ECKLG antibody;EFL 1 antibody;EFL1 antibody;EFNA 1 antibody;Efna1 antibody;EFNA1_HUMAN antibody;EPH related receptor tyrosine kinase ligand 1 antibody;EPH-related receptor tyrosine kinase ligand 1 antibody;Ephrin-A1 antibody;Ephrin-A1, secreted form antibody;EphrinA1 antibody;EPLG 1 antibody;EPLG1 antibody;Immediate early response protein B61 antibody;LERK 1 antibody;LERK-1 antibody;LERK1 antibody;Ligand of eph related kinase 1 antibody;OTTHUMP00000033242 antibody;OTTHUMP00000033271 antibody;secreted form antibody;TNF alpha-induced protein 4 antibody;TNFAIP 4 antibody;TNFAIP4 antibody;Tumor necrosis factor alpha induced protein 4 antibody;Tumor necrosis factor alpha-induced protein 4 antibody

SUBCELLULAR LOCATION

Cell membrane, Secreted.

FUNCTION

Ephrin A1 is a protein that in humans is encoded by the EFNA1 gene. This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin which binds to the EPHA2, EPHA4, EPHA5, EPHA6, and EPHA7 receptors. Two transcript variants that encode different isoforms were identified through sequence analysis. Model organisms have been used in the study of EFNA1 function.