EphA2 (N-term) Rabbit Polyclonal Antibody (ER2001-31)

UNIPROT #

P29317

PROTEIN NAME

EphA2 (N-term)

SYNONYMS

ARCC2 antibody;AW545284 antibody;CTPA antibody;CTPP1 antibody;CTRCT6 antibody;EC 2.7.10.1 antibody;Eck antibody;Eph receptor A2 antibody;EPHA2 antibody;EPHA2_HUMAN antibody;Ephrin receptor antibody;Ephrin receptor EphA2 antibody;Ephrin type A receptor 2 antibody;Ephrin type-A receptor 2 antibody;Epithelial cell kinase antibody;Epithelial cell receptor protein tyrosine kinase antibody;Myk 2 antibody;Myk2 antibody;Sek 2 antibody;Sek2 antibody;Soluble EPHA2 variant 1 antibody;Tyrosine protein kinase receptor ECK antibody;Tyrosine-protein kinase receptor ECK antibody;Tyrosine-protein kinase receptor MPK-5 antibody;Tyrosine-protein kinase receptor SEK-2 antibody

SUBCELLULAR LOCATION

Cell junction, Cell membrane, Cell projection, Membrane.

FUNCTION

Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).