Envelope Glycoprotein Mouse Monoclonal Antibody [A1-A6] (HA601029)

UNIPROT #

P87666

PROTEIN NAME

Envelope Glycoprotein

SYNONYMS

GP 1,2 antibody;GP antibody;GP1 antibody;GP2 antibody;GP2-delta antibody;Spike glycoprotein antibody;Virion spike glycoprotein antibody

SUBCELLULAR LOCATION

Virion membrane, Host cell membrane, Secreted.

FUNCTION

Trimeric GP1,2 complexes form the virion surface spikes and mediate the viral entry processes, with GP1 acting as the receptor-binding subunit and GP2 as the membrane fusion subunit. At later times of infection, downregulates the expression of various host cell surface molecules that are essential for immune surveillance and cell adhesion. Down-modulates several integrins including ITGA1, ITGA2, ITGA3, ITGA4, ITGA5, ITGA6, ITGAV and ITGB1. This decrease in cell adhesion molecules may lead to cell detachment, contributing to the disruption of blood vessel integrity and hemorrhages developed during infection (cytotoxicity). Interacts with host TLR4 and thereby stimulates the differentiation and activation of monocytes leading to bystander death of T-lymphocytes. Downregulates as well the function of host natural killer cells. Counteracts the antiviral effect of host BST2/tetherin that restricts release of progeny virions from infected cells. However, cooperates with VP40 and host BST2 to activate canonical NF-kappa-B pathway in a manner dependent on neddylation.