ENTPD5 Recombinant Rabbit Monoclonal Antibody [JE47-87] (ET7109-70)

UNIPROT #

O75356

PROTEIN NAME

ENTPD5

SYNONYMS

CD39 like 4 antibody;AI196558 antibody;AI987697 antibody;CD39 antigen like 4 antibody;CD39 antigen-like 4 antibody;CD39 like 4 antibody;CD39L4 antibody;Ectonucleoside triphosphate diphosphohydrolase 5 antibody;ENTP5_HUMAN antibody;Entpd5 antibody;ER UDPase antibody;ER-UDPase antibody;GDPase ENTPD5 antibody;Guanosine-diphosphatase ENTPD5 antibody;MGC163357 antibody;MGC163359 antibody;mNTPase antibody;NTPDase 5 antibody;Nucleoside diphosphatase antibody;PCPH antibody;Pcph proto oncogene protein antibody;Proto oncogene CPH antibody;UDPase ENTPD5 antibody;Uridine-diphosphatase ENTPD5 antibody

SEQUENCE SIMILARITIES

Belongs to the GDA1/CD39 NTPase family.

TISSUE SPECIFICITY

Expressed in adult liver, kidney, prostate, testis and colon. Much weaker expression in other tissues.

POST-TRANSLATIONAL MODIFICATION

N-glycosylated; high-mannose type (By similarity). Glycosylation is not essential for enzymatic activity.

SUBCELLULAR LOCATION

Endoplasmic reticulum. Secreted.

FUNCTION

The protein encoded by this gene is similar to E-type nucleotidases (NTPases)/ecto-ATPase/apyrases. NTPases, such as CD39, mediate catabolism of extracellular nucleotides. ENTPD5 contains 4 apyrase-conserved regions which is characteristic of NTPases. Uridine diphosphatase (UDPase) that promotes protein N-glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thiamine pyrophosphate. Plays a key role in the AKT1-PTEN signaling pathway by promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase (PI3K) signaling.