Elongation factor 1-gamma Recombinant Rabbit Monoclonal Antibody [JE54-03] (ET7110-45)

UNIPROT #

P26641

PROTEIN NAME

Elongation factor 1-gamma

SYNONYMS

2610301D06Rik antibody;AA407312 antibody;eEF 1B gamma antibody;EEF 1G antibody;eEF-1B gamma antibody;EEF1G antibody;EF 1 gamma antibody;EF 1G antibody;EF-1-gamma antibody;EF1 gamma antibody;EF1G antibody;EF1G_HUMAN antibody;Elongation factor 1 gamma antibody;Elongation factor 1-gamma antibody;Eukaryotic translation elongation factor 1 gamma antibody;GIG 35 antibody;GIG35 antibody;MGC103354 antibody;MGC114210 antibody;MGC144723 antibody;MGC144724 antibody;MGC94929 antibody;Pancreatic tumor related protein antibody;PRO1608 antibody;Translation elongation factor eEF 1 gamma chain antibody

TISSUE SPECIFICITY

Highly expressed in pancreatic tumor tissue and to a lesser extent in normal kidney, intestine, pancreas, stomach, lung, brain, spleen and liver.

SUBCELLULAR LOCATION

Cytosol, extracellular exosome, nucleus, cytoplasm, membrane.

FUNCTION

This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit contains an N-terminal glutathione transferase domain, which may be involved in regulating the assembly of multisubunit complexes containing this elongation factor and aminoacyl-tRNA synthetases. EF-1 γ (elongation factor 1-gamma), also known as EEF1G or GIG35, is a 437 amino acid subunit of the EF-1 complex. Expressed in stomach, pancreas, brain, lung, kidney, intestine, liver and spleen, EF-1 γ contains an N-terminal glutathione transferase domain which is thought to be involved in anchoring the complex to various cellular components. Additionally, EF-1 γ may play a key role in the assembly of multiprotein complexes containing aminoacyl-tRNA synthetases. Increased expression of EF-1 γ is associated with pancreatic cancer, suggesting a possible role for EF-1 γ in the oncogenic transformation process.