eIF4A3 Recombinant Rabbit Monoclonal Antibody [JG35-33] (ET7108-11)

UNIPROT #

P38919

PROTEIN NAME

eIF4A3

SYNONYMS

ATP-dependent RNA helicase DDX48 antibody;ATP-dependent RNA helicase eIF4A-3 antibody;DDX48 antibody;DEAD box protein 48 antibody;eIF-4A-III antibody;eIF4A-III antibody;EIF4A3 antibody;eIF4AIII antibody;Eukaryotic initiation factor 4A-III antibody;Eukaryotic initiation factor 4A-like NUK-34 antibody;Eukaryotic translation initiation factor 4A isoform 3 antibody;hNMP 265 antibody;IF4A3_HUMAN antibody;NMP 265 antibody;NMP265 antibody;Nuclear matrix protein 265 antibody;NUK34 antibody

SEQUENCE SIMILARITIES

Belongs to the DEAD box helicase family. eIF4A subfamily.

TISSUE SPECIFICITY

Ubiquitously expressed.

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Spliceosome.

FUNCTION

ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Its RNA-dependent ATPase and RNA-helicase activities are induced by CASC3, but abolished in presence of the MAGOH-RBM8A heterodimer, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation.