eIF3B Recombinant Rabbit Monoclonal Antibody [JE54-00] (ET7110-36)

UNIPROT #

P55884

PROTEIN NAME

eIF3B

SYNONYMS

eIF-3-eta antibody;eIF3 eta antibody;eIF3 p110 antibody;eIF3 p116 antibody;EIF3-ETA antibody;EIF3-P110 antibody;EIF3-P116 antibody;eIF3b antibody;EIF3B_HUMAN antibody;EIF3S9 antibody;EIF3S9, formerly antibody;Eukaryotic translation initiation factor 3, subunit B antibody;Eukaryotic translation initiation factor 3 subunit 9 antibody;eukaryotic translation initiation factor 3 subunit 9 eta antibody;Eukaryotic translation initiation factor 3 subunit B antibody;eukaryotic translation initiation factor 3, subunit 9 (eta, 116kD) antibody;eukaryotic translation initiation factor 3, subunit 9 eta, 116kDa antibody;eukaryotic translation initiation factor 3, subunit 9, formerly antibody;hPrt1 antibody;Protein synthesis defective at 36 degrees celsius 1, S. cerevisiae, homolog of antibody;PRT1 antibody;Prt1 homolog antibody

SEQUENCE SIMILARITIES

Belongs to the eIF-3 subunit B family.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated. Phosphorylation is enhanced upon serum stimulation.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.