EFTUD2 Mouse Monoclonal Antibody [1-D10-A1] (M1510-3)

UNIPROT #

O08810

PROTEIN NAME

Eftud2

SYNONYMS

116 kDa antibody;116 kDa U5 small nuclear ribonucleoprotein component antibody;EFTUD2 antibody;Elongation factor Tu GTP binding domain containing 2 antibody;Elongation factor Tu GTP-binding domain-containing protein 2 antibody;hSNU114 antibody;MFDGA antibody;MFDM antibody;SNRNP116 antibody;Snrp116 antibody;Snu114 antibody;SNU114 homolog antibody;U5 116KD antibody;U5 small nuclear ribonucleoprotein component antibody;U5 snRNP specific protein, 116 kD antibody;U5 snRNP specific protein, 116 kDa antibody;U5 snRNP-specific protein antibody;U5-116 kDa antibody;U5-116KD antibody;U5S1_HUMAN antibody

SEQUENCE SIMILARITIES

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Spliceosomes are multi-protein complexes that are composed of snRNPs (small nuclear ribonucleoproteins) and a variety of associated protein factors, all of which work in concert to regulate the splicing of pre-mRNA. Snrp116, also known as EFTUD2 (elongation factor Tu GTP binding domain containing 2) or Snu114, is a 972 amino acid protein that localizes to the nucleus and belongs to the GTP-binding elongation factor family. Existing as a component of the multi-protein U5 snRNP spliceosome complex, Snrp116 plays an important role in pre-mRNA splicing, as well as in the recycling of spliceosomal snRNPs. The gene encoding Snrp116 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes.