E2F2 Recombinant Rabbit Monoclonal Antibody [SN201-04] (ET1611-88)

UNIPROT #

Q14209

PROTEIN NAME

E2F2

SYNONYMS

dE2F2 antibody;E2F transcription factor 2 antibody;E2F-2 antibody;E2F2 antibody;E2F2_HUMAN antibody;Transcription factor E2F2 antibody

SEQUENCE SIMILARITIES

Belongs to the E2F/DP family.

TISSUE SPECIFICITY

Highest level of expression is found in placenta, low levels are found in lung. Found as well in many immortalized cell lines derived from tumor samples.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.