Dynein intermediate chain 1 Recombinant Rabbit Monoclonal Antibody [JM11-38] (ET1705-8)

UNIPROT #

Q9UI46

PROTEIN NAME

Dynein intermediate chain 1

SYNONYMS

Axonemal dynein intermediate chain 1 antibody;Axonemal dynein intermediate chain 2 antibody;CILD 1 antibody;CILD1 antibody;Cytoplasmic dynein 1 intermediate chain 1 antibody;Cytoplasmic dynein 1 intermediate chain 2 antibody;Cytoplasmic dynein intermediate chain 1 antibody;Cytoplasmic dynein intermediate chain 2 antibody;DH IC 1 antibody;DH IC 2 antibody;DIC1 antibody;DNAI 1 antibody;DNAI 2 antibody;DNAI1 antibody;DNAI1_HUMAN antibody;DNAI2 antibody;DNCI 2 antibody;DNCI1 antibody;DNCI2 antibody;DNCIC 1 antibody;DNCIC 2 antibody;DNCIC1 antibody;DNCIC2 antibody;DYNC1I1 antibody;DYNC1I2 antibody;Dynein axonemal intermediate chain 1 antibody;Dynein axonemal intermediate polypeptide 1 antibody;Dynein axonemal intermediate polypeptide 2 antibody;Dynein cytoplasmic intermediate polypeptide 1 antibody;Dynein cytoplasmic intermediate polypeptide 2 antibody;Dynein intermediate chain 1 axonemal antibody;Dynein intermediate chain 1 cytosolic antibody;Dynein intermediate chain 1, axonemal antibody;Dynein intermediate chain 2 axonemal antibody;Dynein intermediate chain 2 cytosolic antibody;Dynein intermediate chain DNAI1 antibody;IC74 antibody;ICS antibody;ICS1 antibody;Immotile cilia syndrome 1 antibody;MGC26204 antibody;PCD antibody

SEQUENCE SIMILARITIES

Belongs to the dynein intermediate chain family.

SUBCELLULAR LOCATION

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Dynein, Microtubule.

FUNCTION

Dyneins are multisubunit, high molecular weight ATPases that interact with microtubules to generate force by converting the chemical energy of ATP into the mechanical energy of movement. Cytoplasmic or axonemal Dynein heavy, intermediate, light and light-intermediate chains are all components of minus end-directed motors; the complex transports cellular cargos towards the central region of the cell. Axonemal Dynein motors contain one to three non-identical heavy chains and cause a sliding of microtubules in the axonemes of cilia and flagella in a mechanism necessary for cilia to beat and propel the cell. Cytoplasmic Dyneins, such as Dynein IC1, cytosolic and Dynein IC2, cytosolic, comprise an approximately 12 subunit complex of two heavy chains, two intermediate chains to anchor Dynein to its cargo, four smaller intermediate chains and several light chains. This complex performs functions necessary for cell survival, such as organelle transport and centrosome assembly. The carboxy terminus of Dynein is important for microtubule-dependent motility and is highly conserved, while the amino terminal regions are more variable. Several proteins regulate Dynein activity, including dynactin, LIS1 and NudEL(NudE-like).