Lane 1: PC-12
Lane 2: Mouse thymus
Lane 3: Hela
Recombinant Rabbit monoclonal primary
Dynamin 2 Recombinant Rabbit Monoclonal Antibody [JM61-38] (ET1705-2)
PC-12, mouse thymus tissue, Hela, 293T, human kidney tissue, human fetal skeletal muscle tissue, mouse testes tissue, mouse colon tissue, mouse fallopian tube tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
CMT2M antibody; CMTDI1 antibody; CMTDIB antibody; DI CMTB antibody; Dnm2 antibody; DYN II antibody; DYN2 antibody; DYN2_HUMAN antibody; Dynamin II antibody; Dynamin-2 antibody; Dynamin2 antibody; DynaminII antibody; DYNII antibody
Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
Phosphorylation at Ser-764 by CDK1 is greatly increased upon mitotic entry. It regulates cytokinesis downstream of calcineurin, and does not affect clathrin-mediated endocytosis. Dephosphorylated by calcineurin/PP2 (By similarity). Phosphorylated on tyrosine residues after activation of SRC (By similarity).
Members of the dynamin family, including Dynamin I and Dynamin II, are GPTase, microtubule-associated proteins which are involved in endocytosis, synaptic transmission and neurogenesis. Dynamin I is localized to the central nervous system, while Dynamin II exhibits ubiquitous distribution with highest expression found in testis. Both dynamin proteins contain SH3 and proline-rich domains that mediate interactions between the dynamins and effectors of their GTPase activity. The interactions with these effectors, which include microtubules, acidic phospholipids and SH3 domain-containing proteins, are required for rapid endocytosis. Dynamin I appears to be recruited to clathrin coated pits by SH3 domain interaction with amphiphysin, a protein highly expressed in brain.