Applications
-
WB
REACTIVITY
-
Mouse
SPECIFICATIONS
Product Type
Rabbit polyclonal primary
Product Name
DPPA2 Rabbit Polyclonal Antibody (0731-4)
Immunogen
Peptide
Host
Rabbit
Positive Control
F9
Conjugation
Unconjugated
Clonality
Polyclonal
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1 ug/ul
PURIFICATION
Immunogen affinity purified
MOLECULAR WEIGHT
37kDa
Isotype
IgG
APPLICATION DILUTION
-
WB
-
1:2,000
TARGET
UNIPROT #
PROTEIN NAME
DPPA2
SYNONYMS
cancer/testis antigen 100 antibody; CT100 antibody; Developmental Pluripotency Associated 2 antibody; developmental pluripotency-associated gene 2 antibody; developmental pluripotency-associated protein 2 antibody; ECAT15-2 antibody; embryonic stem cell (ESC) associated transcript 15-2 antibody; PESCRG1 antibody; Pluripotent embryonic stem cell related protein 1 antibody; Pluripotent embryonic stem cell-related gene 1 antibody; Pluripotent embryonic stem cell-related gene 1 protein antibody
TISSUE SPECIFICITY
Not detected in adult tissues.
DEVELOPMENTAL STAGE
Expressed in 4-cell embryo, morula and blastocyst. At 7.5 dpc, detected in the epiblast. At 10.0 dpc, expressed in the primordial germ cells. Expression decreases at 12.0 dpc in the embryonic gonads. At 14.5 dpc, expression is restricted to testis. 6 days after birth, still detected in primitive type A spermatogonia. Expressed in undifferentiated embryonic stem cells, but expression rapidly decreases upon differentiation.
SUBCELLULAR LOCATION
Nucleus
FUNCTION
DPPA2 (developmental pluripotency associated 2) is an embryo-cancer antigen that is coexpressed with cancer-testis antigens in non-small cell lung cancer. Dppa2 is closely linked SAP motif genes restricted to pluripotent cells and the germ line. It may play a role in maintaining cell pluripotentiality and in embryo preimplantation development.