UNIPROT #

Q9CWH0

PROTEIN NAME

DPPA2

SYNONYMS

cancer/testis antigen 100 antibody; CT100 antibody; Developmental Pluripotency Associated 2 antibody; developmental pluripotency-associated gene 2 antibody; developmental pluripotency-associated protein 2 antibody; ECAT15-2 antibody; embryonic stem cell (ESC) associated transcript 15-2 antibody; PESCRG1 antibody; Pluripotent embryonic stem cell related protein 1 antibody; Pluripotent embryonic stem cell-related gene 1 antibody; Pluripotent embryonic stem cell-related gene 1 protein antibody

TISSUE SPECIFICITY

Not detected in adult tissues.

DEVELOPMENTAL STAGE

Expressed in 4-cell embryo, morula and blastocyst. At 7.5 dpc, detected in the epiblast. At 10.0 dpc, expressed in the primordial germ cells. Expression decreases at 12.0 dpc in the embryonic gonads. At 14.5 dpc, expression is restricted to testis. 6 days after birth, still detected in primitive type A spermatogonia. Expressed in undifferentiated embryonic stem cells, but expression rapidly decreases upon differentiation.

SUBCELLULAR LOCATION

Nucleus

FUNCTION

DPPA2 (developmental pluripotency associated 2) is an embryo-cancer antigen that is coexpressed with cancer-testis antigens in non-small cell lung cancer. Dppa2 is closely linked SAP motif genes restricted to pluripotent cells and the germ line. It may play a role in maintaining cell pluripotentiality and in embryo preimplantation development.