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DP2 Rabbit Polyclonal Antibody (HA500228)

Price: Regular price $315.00

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Catalog# HA500228

Rabbit Polyclonal to DP2

Tested for

  • WB

  • IHC-P

Reacts with

  • Human

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Specifications

Product Type

Rabbit polyclonal primary

Product Name

DP2 Rabbit Polyclonal Antibody (HA500228)

Immunogen

Recombinant protein within human dp2 aa 50-250.

Host

Rabbit

Positive Control

Hela cell lysate, Daudi cell lysate, K562 cell lysate, 293T cell lysate, PC-3 cell lysate, human colon carcinoma tissue, human skin tissue.

Conjugation

Unconjugated

Clonality

Polyclonal

RRID

AB_3071325

APPLICATION DILUTION

  • WB

  • 1:1,000-1:2,000

  • IHC-P

  • 1:200

PROPERTIES

Form

Liquid

Storage Condition

Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.

Storage Buffer

1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1ug/ul

Purification

Immunogen affinity purified.

Molecular Weight

Predicted band size: 49 kDa.

Isotype

IgG

TARGET

UNIPROT #

Q14188

PROTEIN NAME

DP2

SYNONYMS

DP2 antibody;E2F dimerization partner 2 antibody;Tfdp2 antibody;TFDP2_HUMAN antibody;Transcription factor Dp 2 antibody;Transcription factor Dp-2 antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants. Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTC[CG]CGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The TFDP2:E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters.

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