DP1 Recombinant Rabbit Monoclonal Antibody [JE52-55] (ET7110-43)

UNIPROT #

Q14186

PROTEIN NAME

DP1

SYNONYMS

DP 1 antibody;DP1 antibody;DRTF1 antibody;DRTF1-polypeptide 1 antibody;E2F dimerization partner 1 antibody;E2F related transcription factor antibody;TFDP1 antibody;TFDP1_HUMAN antibody;Transcription factor Dp-1 antibody;Transcription factor sequence-specific, DRTF1 antibody

SEQUENCE SIMILARITIES

Belongs to the E2F/DP family.

TISSUE SPECIFICITY

Highest levels in muscle. Also expressed in brain, placenta, liver and kidney. Lower levels in lung and pancreas. Not detected in heart.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation by E2F1-bound cyclin A-CDK2, in the S phase, inhibits E2F-mediated DNA binding and transactivation.; Ubiquitinated by the BCR(KBTBD5) complex, leading to its subsequent degradation.

SUBCELLULAR LOCATION

Nucleus, cytoplasm.

FUNCTION

This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X. E2F factors bind to DNA as homodimers or heterodimers in association with dimerization partner DP1. TFDP1 may be the first example of a family of related transcription factors.