PRODUCT CODE: ET1704-94

DOPA Decarboxylase Recombinant Rabbit Monoclonal Antibody [JA53-16] (ET1704-94)

  • Recombinant

Applications

  • WB

  • IHC-P

REACTIVITY

  • Human

  • Mouse

  • Rat

Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-DOPA Decarboxylase antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-DOPA Decarboxylase antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded human liver tissue using anti-DOPA Decarboxylase antibody. Counter stained with hematoxylin.
Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-DOPA Decarboxylase antibody. Counter stained with hematoxylin.

Applications

  • WB

  • IHC-P

REACTIVITY

  • Human

  • Mouse

  • Rat

SPECIFICATIONS

Product Type

Recombinant Rabbit monoclonal primary

Product Name

DOPA Decarboxylase Recombinant Rabbit Monoclonal Antibody [JA53-16] (ET1704-94)

Immunogen

Recombinant protein

Host

Rabbit

Positive Control

Human liver tissue, human kidney tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JA53-16

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Protein A purified.

MOLECULAR WEIGHT

53 kDa

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:500-1:1,000

  • IHC-P

  • 1:50-1:200

TARGET

UNIPROT #

PROTEIN NAME

DOPA Decarboxylase

SYNONYMS

AADC antibody; Aromatic L Amino Acid Decarboxylase antibody; Aromatic-L-amino-acid decarboxylase antibody; Ddc antibody; DDC_HUMAN antibody; DOPA decarboxylase (aromatic L-amino acid decarboxylase) antibody; DOPA decarboxylase antibody

SEQUENCE SIMILARITIES

Belongs to the group II decarboxylase family.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

DOPA decarboxylase (DDC), also designated aromatic-L-amino-acid decarboxylase (AADC) belongs to the group II decarboxylase family of proteins. DDC, which can form a homodimer, is an important protein in the catecholamine biosynthesis pathway. DDC acts as a catalyst in the decarboxylation of L-5-hydroxytryptophan to serotonin, L-3,4-dihydroxyphenylalanine (DOPA) to dopamine and L-tryptophan to tryptamine. Defects in the gene encoding for DDC may cause the autosomal recessive disorder AADC deficiency. AADC deficiency is an early onset inborn error in neurotransmitter metabolism which can lead to catecholamine and serotonin deficiency. This causes poor feeding, psychomotor and developmental delays, lethargy, ptosis, gastrointestinal disturbances and hypothermia.