UNIPROT #

Q8N1I0

PROTEIN NAME

DOCK4

SYNONYMS

Dedicator of cytokinesis protein 4 antibody; Dock4 antibody; DOCK4_HUMAN antibody; KIAA0716 antibody

SEQUENCE SIMILARITIES

Belongs to the DOCK family.

TISSUE SPECIFICITY

Widely expressed at low level. Highly expressed in skeletal muscle, prostate and ovary.; [Isoform 2]: May be specifically expressed in the brain and eye.

SUBCELLULAR LOCATION

Cytosol. Cell membrane.

FUNCTION

DOCK 4 (Dedicator of cytokinesis protein 4) is a cytoplasmic peripheral membrane protein that belongs to the DOCK family of cytokinesis-regulating proteins. Expressed ubiquitously with highest expression in prostate, ovary and skeletal muscle, DOCK 4 functions as a guanine nucleotide exchange factor (GEF) that activates the small GTPase Rap 1 and, via this activation, plays a role in the regulation of adherens junctions between cells. Similar to other DOCK family members, DOCK 4 contains an N-terminal SH3 domain, a C-terminal proline-rich region and two internal DOCK homology regions designated DHR1 and DHR2. Defects in the gene encoding DOCK 4 result in the inactivation of Rap 1 and are, thus, implicated in the pathogenesis of various cancers such as ovarian, prostate, glioma and colorectal carcinomas. Four isoforms of DOCK 4 are expressed due to alternative splicing events.