DNA Ligase I Recombinant Rabbit Monoclonal Antibody [JB43-39] (ET7107-14)

UNIPROT #

P18858

PROTEIN NAME

DNA Ligase I

SYNONYMS

DNA ligase 1 antibody;DNA ligase I antibody;DNLI1_HUMAN antibody;LIG 1 antibody;lig1 antibody;Ligase I DNA ATP dependent antibody;MGC117397 antibody;MGC130025 antibody;Polydeoxyribonucleotide synthase [ATP] 1 antibody

SEQUENCE SIMILARITIES

Belongs to the ATP-dependent DNA ligase family.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

DNA ligase 1 is an enzyme that in humans is encoded by the LIG1 gene. DNA ligase I is the only known eukaryotic DNA ligase involved in both DNA replication and repair, making it the most studied of the ligases. LIG1 encodes DNA ligase I, which functions in DNA replication and the base excision repair process. Eukaryotic DNA ligase 1 catalyzes a reaction that is chemically universal to all ligases. DNA ligase 1 utilizes adenosine triphosphate (ATP) to catalyze the energetically favorable ligation events in both DNA replication and repair. During the synthesis phase (S-phase) of the eukaryotic cell cycle, DNA replication occurs. DNA ligase 1 is responsible for joining Okazaki fragments formed during discontinuous DNA synthesis on the DNA's lagging strand after DNA polymerase δ has replaced the RNA primer nucleotides with DNA nucleotides. If the Okazaki fragments are not properly ligated together, the unligated DNA (containing a ‘nick’) could easily degrade to a double strand break, a phenomenon known to cause genetic mutations.