DISC1 Recombinant Rabbit Monoclonal Antibody [JE35-55] (HA722727)

UNIPROT #

Q9NRI5

PROTEIN NAME

DISC1

SYNONYMS

C1orf136 antibody;DISC1 antibody;DISC1_HUMAN antibody;Disrupted in schizophrenia 1 antibody;Disrupted in schizophrenia 1 protein antibody;KIAA0457 antibody;RP4-730B13.1 antibody;SCZD9 antibody

SUBCELLULAR LOCATION

Cytoplasm, cytoskeleton, Mitochondrion, microtubule organizing center, centrosome, Postsynaptic density.

FUNCTION

Disrupted in schizophrenia 1 is a protein that in humans is encoded by the DISC1 gene. In coordination with a wide array of interacting partners, DISC1 has been shown to participate in the regulation of cell proliferation, differentiation, migration, neuronal axon and dendrite outgrowth, mitochondrial transport, fission and/or fusion, and cell-to-cell adhesion. Several studies have shown that unregulated expression or altered protein structure of DISC1 may predispose individuals to the development of schizophrenia, clinical depression, bipolar disorder, and other psychiatric conditions. The cellular functions that are disrupted by permutations in DISC1, which lead to the development of these disorders, have yet to be clearly defined and are the subject of current ongoing research. Although, recent genetic studies of large schizophrenia cohorts have failed to implicate DISC1 as a risk gene at the gene level,[6] the DISC1 interactome gene set was associated with schizophrenia, showing evidence from genome-wide association studies of the role of DISC1 and interacting partners in schizophrenia susceptibility.