0610041G12Rik antibody;DBLOH_HUMAN antibody;DBOH antibody;DFNA64 antibody;diablo antibody;Diablo homolog (Drosophila) antibody;Diablo homolog antibody;Diablo homolog mitochondrial antibody;Diablo IAP binding mitochondrial protein antibody;Diablo like protein antibody;DIABLO S antibody;Direct IAP binding protein with low pI antibody;Direct IAP-binding protein with low pI antibody;FLJ10537 antibody;FLJ25049 antibody;mitochondrial antibody;Mitochondrial Smac protein antibody;Second mitochondria derived activator of caspase antibody;Second mitochondria-derived activator of caspase antibody;SMAC 3 antibody;Smac antibody;Smac protein antibody;SMAC3 antibody
Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed.
Ubiquitinated by BIRC7/livin.
The activation of caspases is a key regulatory step in apoptosis. Once cytochrome c is released from the mitochondria into the cytosol, it binds Apaf-1 to form an oligomeric cytochrome c/Apaf-1 complex, which induces caspase activation. Inhibitors of Apoptosis Proteins (IAPs), are a family of proteins that regulate the cytochrome c/Apaf-1 caspase activating pathway. Like cytochrome c, Smac (for second mitochondria-derived activator of caspase, also designated DIABLO in mouse for direct IAP binding protein with low PI) promotes caspase activation in the cytochrome c/Apaf-1/caspase-9 pathway by binding IAPs and preventing them from inhibiting caspases. In healthy cells, Smac is a mitochondrial protein, but when cells undergo apoptosis, Smac is released into the cytosol.
Just like the interactions between antigens and antibodies, the higher the affinity between you and us the better.