Rabbit polyclonal primary
Desmoglein 3 Rabbit Polyclonal Antibody (ER1901-81)
Recombinant protein within human dsg3 aa 700-880.
A431 cell lysates, A549, Hela, rat esophagus tissue, human esophagus cancer tissue, mouse skin tissue.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein affinity purified.
Predicted band size 108 kDa.
130 kD pemphigus vulgaris antigen antibody; 130 kDa pemphigus vulgaris antigen antibody; Balding antibody; Cadherin family member 6 antibody; CDHF 6 antibody; CDHF6 antibody; Desmoglein 3 antibody; Desmoglein 3 precursor antibody; Desmoglein-3 antibody; Desmoglein3 antibody; DKFZp686P23184 antibody; DSG 3 antibody; DSG3 antibody; DSG3_HUMAN antibody; Pemphigus vulgaris antigen antibody; PVA antibody
Epidermis, tongue, tonsil, esophagus and carcinomas.
Pemphigus is an autoimmune disease of skin adhesion associated with auto-antibodies against a number of keratinocyte antigens, such as the adhesion molecules desmoglein (dsg) 1 and 3 and acetylcholine receptors. Desmogleins, type I membrane proteins, are important for cell adhesion and are expressed in great abundance at the desmosomes, which are adhesive cell junctions. Desmogleins belong to the cadherin family and consist of dsg1, dsg2 and dsg3. Calcium binds to the putative calcium binding sites at the extracellular N-terminal domain, which has cadherin-like repeats. Unlike normal human keratinocytes, the squamous cell carcinoma cells exhibit diminished or un-usual expression of dsg3 and dsg1, which bear pemphigus vulgaris and pemphigus foliaceus antigens, respectively. Several carcinoma cell lines constantly express dsg2 and dsg3 mRNA, whereas cultured normal human keratinocytes always express dsg1 and dsg3 mRNA, with or without dsg2 mRNA. This expression pattern indicates that desmoglein isoforms exhibit abnormal expression and may be related to tumor cell kinetics, such as cell invasion and metastasis. dsg2 is the fundamental dsg common to all desmosome-possessing tissues and is the largest desmoglein in the family.