Lane 1: rat skin tissue lysate
Lane 2: A431 cell lysate
Recombinant Rabbit monoclonal primary
Desmocollin 3 Recombinant Rabbit Monoclonal Antibody [JE55-86] (ET7111-26)
Synthetic peptide within c-terminal human desmocollin 3.
Rat skin tissue lysate, A431 cell lysate, 293T, human skin tissue, mouse esophagus tissue, A431.
Store at +4Á¾ after thawing. Aliquot store at -20Á¾. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
Predicted band size: 100 kDa.
Cadherin family member 3 antibody; CDHF3 antibody; desmocollin 3a/3b antibody; Desmocollin 4 antibody; Desmocollin-3 antibody; Desmocollin-4 antibody; Desmocollin3 antibody; Desmocollin4 antibody; DSC antibody; DSC1 antibody; DSC2 antibody; DSC3 antibody; DSC3_HUMAN antibody; DSC4 antibody; HT CP antibody; HT-CP antibody; HTCP antibody
Cell membrane, desmosome.
The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants.