DDR2 Mouse Monoclonal Antibody [A9H5] (HA601150)

UNIPROT #

Q16832

PROTEIN NAME

DDR2

SYNONYMS

CD167 antigen-like family member B antibody;CD167b antibody;CD167b antigen antibody;Cell migration inducing protein 20 antibody;DDR 2 antibody;DDR2 antibody;DDR2_HUMAN antibody;Discoidin domain containing receptor 2 antibody;Discoidin domain receptor 2 antibody;Discoidin domain receptor family member 2 antibody;discoidin domain receptor tyrosine kinase 2 antibody;Discoidin domain-containing receptor 2 antibody;discoidin domain-containing receptor tyrosine kinase 2 antibody;Hydroxyaryl protein kinase antibody;MIG20a antibody;Migration inducing gene 16 protein antibody;Neurotrophic tyrosine kinase antibody;Neurotrophic tyrosine kinase receptor related 3 antibody;NTRKR 3 antibody;NTRKR3 antibody;Receptor protein tyrosine kinase TKT antibody;Receptor protein-tyrosine kinase TKT antibody;Receptor related 3 antibody;receptor-related 3 antibody;TKT antibody;TYRO 10 antibody;TYRO10 antibody;Tyrosine kinase receptor related to neurotrophic TRK antibody;Tyrosine protein kinase TYRO 10 antibody;Tyrosine protein kinase TYRO10 antibody;Tyrosine-protein kinase TYRO10 antibody;Tyrosylprotein kinase antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Discoidin domain-containing receptor 2, also known as CD167b (cluster of differentiation 167b), is a protein that in humans is encoded by the DDR2 gene. Discoidin domain-containing receptor 2 is a receptor tyrosine kinase (RTK). RTKs play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. In the case of DDR2, the ligand is collagen which binds to its extracellular discoidin domain. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. DDR2 has been associated with a number of diseases including fibrosis and cancer. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain.