DDB1 Rabbit Polyclonal Antibody (R1706-21)

UNIPROT #

Q16531

PROTEIN NAME

DDB1

SYNONYMS

Damage specific DNA binding protein 1 antibody;Damage-specific DNA-binding protein 1 antibody;DDB 1 antibody;DDB p127 subunit antibody;Ddb1 antibody;DDB1_HUMAN antibody;DDBa antibody;DNA damage binding protein 1 antibody;DNA damage-binding protein 1 antibody;DNA damage-binding protein a antibody;HBV X-associated protein 1 antibody;UV damaged DNA binding factor antibody;UV damaged DNA binding protein 1 antibody;UV DDB 1 antibody;UV DDB1 antibody;UV-damaged DNA-binding factor antibody;UV-damaged DNA-binding protein 1 antibody;UV-DDB 1 antibody;X associated protein 1 antibody;XAP 1 antibody;XAP-1 antibody;XAP1 antibody;Xeroderma pigmentosum group E complementing protein antibody;Xeroderma pigmentosum group E-complementing protein antibody;XPCe antibody;XPE antibody;XPE BF antibody;XPE binding factor antibody;XPE-BF antibody;XPE-binding factor antibody

SEQUENCE SIMILARITIES

Belongs to the DDB1 family.

POST-TRANSLATIONAL MODIFICATION

Phosphorylated by ABL1.; Ubiquitinated by CUL4A. Subsequently degraded by ubiquitin-dependent proteolysis.; Acetylated, promoting interaction with CUL4 (CUL4A or CUL4B) and subsequent formation of DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Deacetylation by SIRT7 impairs the interaction with CUL4 (CUL4A or CUL4B) and formation of DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes.

SUBCELLULAR LOCATION

Nucleus. Cytoplasm.

FUNCTION

Damaged DNA binding protein (DDB) is a heterodimer composed of two subunits, p127 and p48, which are designated DDB1 and DDB2, respectively. The DDB heterodimer is involved in repairing DNA damaged by ultraviolet light. Specifically, DDB, also designated UV-damaged DNA binding protein (UV-DDB), xeroderma pigmentosum group E binding factor (XPE-BF) and hepatitis B virus X-associated protein 1 (XAP-1), binds to damaged cyclobutane pyrimidine dimers (CPDs). Mutations in the DDB2 gene are implicated as causes of xeroderma pigmentosum group E, an autosomal recessive disease in which patients are defective in nucleotide excision DNA repair. XPE is characterized by hypersensitivity of the skin to sunlight with a high frequency of skin cancer as well as neurologic abnormalities. The hepatitis B virus (HBV) X protein interacts with DDB1, which may mediate HBx transactivation.