Lane 1: Rat heart
Lane 2: Mouse heart
Lane 3: Mouse lung
Lane 4: Human lung
Recombinant Rabbit monoclonal primary
DDAH2 Recombinant Rabbit Monoclonal Antibody [JB59-33] (ET7107-41)
Synthetic peptide within human ddah2 aa 1-100
Rat heart tissue lysate, mouse heart tissue lysate, mouse lung tissue lysate, human lung tissue lysate.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
DDAH antibody; DDAH II antibody; DDAH-2 antibody; DDAH2 antibody; DDAH2_HUMAN antibody; DDAHII antibody; Dimethylargininase 2 antibody; Dimethylargininase-2 antibody; Dimethylarginine dimethylaminohydrolase 2 antibody; Dimethylarginine dimethylaminohydrolase II antibody; G6a antibody; N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 antibody; NG dimethylarginine dimethylamino hydrolase homolog antibody; NG30 antibody; OTTHUMP00000029307 antibody; OTTHUMP00000029310 antibody; OTTHUMP00000174488 antibody; OTTHUMP00000174489 antibody; Protein G6a antibody; S phase protein antibody; S-phase protein antibody
Belongs to the DDAH family.
Detected in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas, and at very low levels in brain.
DDAH, a dimethylarginine dimethylaminohydrolase, hydrolyzes dimethyl arginine (ADMA) and monomethyl arginine (MMA), both inhibitors of nitric oxide synthases, and may be involved in in-vivo modulation of nitric oxide production. Impairment of DDAH causes ADMA accumulation and a reduction in cGMP generation. DDAH II, the predominant DDAH isoform in endothelial cells, facilitates the induction of nitric oxide synthesis by all-trans-Retinoic acid (atRA). DDAH proteins are highly expressed in colon, kidney, stomach and liver tissues.