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PRODUCT CODE: ET1705-71

DDAH1 Recombinant Rabbit Monoclonal Antibody [JM53-18] (ET1705-71)

  • Recombinant

Applications

  • WB

  • IHC-P

  • IP

REACTIVITY

  • Human

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Western blot analysis of DDAH1 on human kidney (1) and human liver (2) tissue lysate using anti-DDAH1 antibody at 1/1,000 dilution.
  • Western blot analysis of DDAH1 on human kidney (1) and human liver (2) tissue lysate using anti-DDAH1 antibody at 1/1,000 dilution.
  • Immunohistochemical analysis of paraffin-embedded human prostate tissue using anti-DDAH1 antibody. Counter stained with hematoxylin.
  • Immunohistochemical analysis of paraffin-embedded human kidney tissue using anti-DDAH1 antibody. Counter stained with hematoxylin.
Western blot analysis of DDAH1 on human kidney (1) and human liver (2) tissue lysate using anti-DDAH1 antibody at 1/1,000 dilution.

Applications

  • WB

  • IHC-P

  • IP

REACTIVITY

  • Human

SPECIFICATIONS

Product Type

Recombinant Rabbit monoclonal primary

Product Name

DDAH1 Recombinant Rabbit Monoclonal Antibody [JM53-18] (ET1705-71)

Immunogen

Recombinant protein

Host

Rabbit

Positive Control

Human kidney tissue lysate, human liver tissue lysate, human prostate tissue, human kidney tissue.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

JM53-18

PROPERTIES

Form

Liquid

Storage Condition

Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.

Storage Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Concentration

1 ug/ul

PURIFICATION

Protein A purified.

Isotype

IgG

APPLICATION DILUTION

  • WB

  • 1:500-1:2,000

  • IHC-P

  • 1:50-1:200

TARGET

UNIPROT #

O94760

PROTEIN NAME

DDAH1

SYNONYMS

DDAH antibody; DDAH I antibody; DDAH-1 antibody; DDAH1 antibody; DDAH1_HUMAN antibody; DDAHI antibody; Dimethylargininase 1 antibody; Dimethylargininase-1 antibody; Dimethylarginine dimethylaminohydrolase 1 antibody; N(G) antibody; N(G)-dimethylarginine dimethylaminohydrolase 1 antibody; NG NG dimethylarginine dimethylaminohydrolase antibody

SEQUENCE SIMILARITIES

Belongs to the DDAH family.

TISSUE SPECIFICITY

Detected in brain, liver, kidney and pancreas, and at low levels in skeletal muscle.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

DDAH, a dimethylarginine dimethylaminohydrolase, hydrolyzes dimethyl arginine (ADMA) and monomethyl arginine (MMA), both inhibitors of nitric oxide synthases, and may be involved in in-vivo modulation of nitric oxide production. Impairment of DDAH causes ADMA accumulation and a reduction in cGMP generation. DDAH II, the predominant DDAH isoform in endothelial cells, facilitates the induction of nitric oxide synthesis by all-trans-Retinoic acid (atRA). DDAH proteins are highly expressed in colon, kidney, stomach and liver tissues.