DCTN1 / p150-glued Recombinant Rabbit Monoclonal Antibody [PSH13-45] (HA723534)

UNIPROT #

Q14203

PROTEIN NAME

DCTN1 / p150-glued

SYNONYMS

150 kDa dynein associated polypeptide antibody;150 kDa dynein-associated polypeptide antibody;DAP 150 antibody;DAP-150 antibody;DAP150 antibody;DCTN 1 antibody;DCTN1 antibody;DCTN1_HUMAN antibody;DP 150 antibody;DP-150 antibody;DP150 antibody;Dynactin 1 (p150 Glued (Drosophila) homolog) antibody;Dynactin 1 (p150 glued homolog Drosophila) antibody;Dynactin 1 antibody;Dynactin subunit 1 antibody;Dynactin1 antibody;HMN7B antibody;p135 antibody;p150 Glued (Drosophila) homolog antibody;p150 glued antibody;p150 glued homolog antibody;p150(GLUED) DROSOPHILA HOMOLOG OF antibody;p150-glued antibody;p150glued antibody

SUBCELLULAR LOCATION

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole, spindle, Nucleus envelope, cell cortex.

FUNCTION

Dynactin subunit 1 is a protein that in humans is encoded by the DCTN1 gene. This gene encodes the largest subunit of dynactin, a macromolecular complex consisting of 23 subunits (11 individual proteins ranging in size from 22 to 150 kD). Dynactin binds to cytoplasmic dynein, dynein cargo adaptors, and microtubules. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is commonly referred to p150-glued. It is present in two copies per dynactin complex and forms an ≈75 nm long flexible arm that extends from the main body of dynactin. The p150-glued arm contains binding sites for microtubules, the microtubule plus tip binding protein EB1, and the N-terminus of the dynein intermediate chain. Alternative splicing of this gene results in at least 2 functionally distinct isoforms: a ubiquitously expressed one and a brain-specific one. Based on its cytogenetic location, this gene is considered as a candidate gene for limb-girdle muscular dystrophy.