DCC Recombinant Rabbit Monoclonal Antibody [PSH12-73] (HA723484)

UNIPROT #

P43146

PROTEIN NAME

DCC

SYNONYMS

Colorectal cancer related chromosome sequence 18 antibody;Colorectal cancer suppressor antibody;CRC 18 antibody;CRC18 antibody;CRCR 1 antibody;CRCR1 antibody;DCC antibody;DCC_HUMAN antibody;Deleted in colorectal cancer protein antibody;Deleted in colorectal carcinoma antibody;Immunoglobulin superfamily DCC subclass member 1 antibody;Netrin receptor DCC antibody;Tumor suppressor protein DCC antibody

SUBCELLULAR LOCATION

Membrane.

FUNCTION

The DCC (Deleted in Colorectal Carcinoma) gene encodes a single-pass transmembrane receptor that functions as a receptor for netrin, a key axon guidance molecule in the developing nervous system. DCC plays a critical role in mediating axon attraction by binding to netrin ligands, guiding neuronal growth cones during neural development. Additionally, DCC can associate with UNC5 family proteins to trigger axon repulsion, highlighting its dual role in axon guidance. Beyond its role in the nervous system, DCC acts as a dependence receptor. In the absence of netrin ligand, DCC induces apoptosis, suggesting its function as a tumor suppressor. DCC has long been implicated in colorectal cancer, and its loss or epigenetic silencing is frequently observed in various cancers, supporting its role in tumor suppression. Recent research has revived interest in DCC as a potential therapeutic target due to its ligand-dependent tumor suppressor activity.