DC-SIGN Recombinant Rabbit Monoclonal Antibody [JE31-24] (HA721382)

UNIPROT #

Q9NNX6

PROTEIN NAME

DC-SIGN

SYNONYMS

C type lectin domain family 4 member L antibody;C-type lectin domain family 4 member L antibody;CD 209 antibody;CD209 antibody;CD209 antigen antibody;CD209 antigen-like protein A antibody;CD209 molecule antibody;CD209_HUMAN antibody;Cd209a antibody;CDSIGN antibody;CIRE antibody;CLEC4L antibody;DC SIGN antibody;DC SIGN1 antibody;DC-SIGN antibody;DC-SIGN1 antibody;DCSIGN antibody;Dendritic cell specific ICAM 3 grabbing nonintegrin 1 antibody;Dendritic cell specific ICAM3 grabbing nonintegrin 1 antibody;Dendritic cell-specific ICAM-3-grabbing non-integrin 1 antibody;Dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin antibody;Dengue fever, protection against, included antibody;Dentritic Cell Specific ICAM3 Grabbing Nonintegrin antibody;HIV GP120 Binding Protein antibody;MGC129965 antibody;MGC130443 antibody;SIGN-R1 antibody;SIGNR5 antibody

SUBCELLULAR LOCATION

Cell membrane; Secreted.

FUNCTION

DC-SIGN (Dendritic Cell-Specific Intercellular adhesion molecule-3-Grabbing Non-integrin) also known as CD209 (Cluster of Differentiation 209) is a protein which in humans is encoded by the CD209 gene. DC-SIGN is a C-type lectin receptor present on the surface of both macrophages and dendritic cells. DC-SIGN on macrophages recognises and binds with high affinity to high-mannose type N-glycans, a class of PAMPs (pathogen associated molecular patterns) commonly found on viruses, bacteria and fungi. This binding interaction activates phagocytosis. On myeloid and pre-plasmacytoid dendritic cells DC-SIGN mediates dendritic cell rolling interactions with blood endothelium and activation of CD4+ T cells, as well as recognition of pathogen haptens. DC-SIGN is a C-type lectin and has a high affinity for the ICAM3 molecule. It binds various microorganisms by recognizing high-mannose-containing glycoproteins on their surface, and can function as a co-receptor for several viruses such as HIV and Hepatitis C. Binding to DC-SIGN can promote HIV and Hepatitis C virus to infect target cells (T-cells and hepatocytes, respectively). Besides functioning as an adhesion molecule, recent studies have also shown that DC-SIGN can initiate innate immunity by modulating toll-like receptors, though the detailed mechanism is not yet known. DC-SIGN together with other C-type lectins is involved in recognition of tumors by dendritic cells. DC-SIGN is also a potential engineering target for dendritic cell based cancer vaccine.