DAG1 Recombinant Rabbit Monoclonal Antibody [PSH13-91] (HA723584)

UNIPROT #

Q14118

PROTEIN NAME

DAG1

SYNONYMS

156DAG antibody;A3a antibody;Agrin receptor antibody;AGRNR antibody;Alpha-DG antibody;alpha-DG-N antibody;Beta-DG antibody;Beta-dystroglycan antibody;DAG antibody;Dag1 antibody;DAG1_HUMAN antibody;Dystroglycan 1 (dystrophin-associated glycoprotein 1) antibody;Dystroglycan antibody;Dystroglycan, alpha antibody;Dystrophin-associated glycoprotein 1 antibody;MDDGC7 antibody;MDDGC9 antibody;OTTHUMP00000210857 antibody;OTTHUMP00000210858 antibody

SUBCELLULAR LOCATION

Secreted, extracellular space; Cell membrane, Cytoplasm, cytoskeleton, Nucleus, nucleoplasm, sarcolemma, Postsynaptic cell membrane.

FUNCTION

Dystroglycan (DG) is a cell surface receptor for several extracellular matrix molecules including laminins, Agrin and Perlecan. Dystroglycan function is required for the formation of basement membranes in early development and the organization of Laminin on the cell surface. α-dystroglycan is a membrane- associated, extracellular glycoprotein that is anchored to the cell-membrane by binding to the transmembrane glycoprotein α-dystroglycan to form an α/β-dystroglycan-complex. Additionally, dystroglycan is part of a multimolecular complex, where it associates with dystrophin, at the sarcolemma, to form the dystrophin-associated protein complex, or with utrophin, at the neuromuscular junction, to form the utrophin-associated protein complex. Dystroglycan is also thought to participate in the clustering of nicotinic acetylcholine receptors at the neuromuscular junction.