D4 GDI Rabbit Polyclonal Antibody (HA500217)

UNIPROT #

P52566

PROTEIN NAME

D4 GDI

SYNONYMS

Arhgdib antibody;D4 antibody;D4 GDP dissociation inhibitor antibody;GDIA 2 antibody;GDIA2 antibody;GDID 4 antibody;GDID4 antibody;GDIR2_HUMAN antibody;GDP dissociation inhibitor D4 antibody;LY GDI antibody;Ly-GDI antibody;LYGDI antibody;MGC108926 antibody;RAP1GN1 antibody;Rho GDI 2 antibody;Rho GDI beta antibody;Rho GDI2 antibody;Rho GDP dissociation inhibitor (GDI) beta antibody;Rho GDP dissociation inhibitor 2 antibody;Rho GDP dissociation inhibitor beta antibody;Rho GDP-dissociation inhibitor 2 antibody;Rho-GDI beta antibody;RhoGDI2 antibody

SUBCELLULAR LOCATION

Cytosol.

FUNCTION

The Ras superfamily of small GTP-binding proteins are critical mediators of diverse cell signaling pathways, including those leading to proliferation, cytoskeletal organization and secretion. The counter-conversion of the active GTP-bound form of these proteins to their inactive GDP-bound form is influenced by two types of regulatory proteins: those that alter the intrinsic GTPase activity of the GTP-binding proteins and those that alter the rate of GDP/GTP exchange. Guanine nucleotide-releasing factors (GRFs) increase the GDP dissociation rate, while GDP-dissociation inhibitors (GDIs) decrease the dissociation rate. The Rho GDI subfamily is composed of Rho GDIα, Ly-GDI (also known as Rho GDIβ and previously known as GDI/D4) and Rho GDIγ. The Rho GDI proteins interact with and have varying affinities for several Ras-like GTP binding proteins, including Rho A, Rho B, Rac and Cdc42. Ly-GDI is expressed only in hematopoietic cells, predominantly in B and T lymphocyte cell lines.