Recombinant Rabbit monoclonal primary
Cytokeratin 9 Recombinant Rabbit Monoclonal Antibody [SD201-09] (ET1612-77)
Mouse skin tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
CK 9 antibody; CK-9 antibody; Cytokeratin 9 antibody; Cytokeratin-9 antibody; Cytokeratin9 antibody; EPPK antibody; K1C9_HUMAN antibody; K9 antibody; Keratin 9 antibody; Keratin antibody; Keratin type I cytoskeletal 9 antibody; Keratin-9 antibody; Keratin9 antibody; KRT 9 antibody; Krt9 antibody; Spermatid Perinuclear Ring Manchette Protein K9 antibody; type I cytoskeletal 9 antibody
Belongs to the intermediate filament family.
Expressed in the terminally differentiated epidermis of palms and soles.
Extracellular exosome, membrane, nucleus.
Cytokeratins comprise a diverse group of intermediate filament proteins that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratin 9 is an unusually large, type I acidic cytokeratin that differentiates human plantar and palmar epidermal cells. Cytokeratin 9 localizes to the suprabasal layers as well as the upper epidermal layers such as the glandular ridges and interridges. The domains of cytokeratin 9 include a head, an α-helical coiled-coil-forming rod, and a tail; cytokeratin 9 shares significant homology with cytokeratin 10. Mutations in the cytokeratin 9 gene correlate with the development of epidermolytic palmoplantar keratoderma (EPPK), an autosomal dominant inherited skin disorder that is characterized by hyperkeratosis of the skin over the palms and soles.