Cytokeratin 5+6 Rabbit Polyclonal Antibody (HA500508)

UNIPROT #

P13647

PROTEIN NAME

Cytokeratin 5+6

SYNONYMS

58 kDa cytokeratin antibody;CK-5 antibody;CK5 antibody;Cytokeratin-5 antibody;Cytokeratin5 antibody;DDD antibody;DDD1 antibody;EBS2 antibody;epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types antibody;K2C5_HUMAN antibody;K5 antibody;keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types) antibody;Keratin 5 antibody;Keratin antibody;keratin complex 2, basic, gene 5 antibody;keratin, type II cytoskeletal 5 antibody;Keratin-5 antibody;Keratin5 antibody;KRT 5 antibody;Krt5 antibody;KRT5A antibody;type II cytoskeletal 5 antibody;Type-II keratin Kb5 antibody;CK6 antibody;CK 6A antibody;CK 6B antibody;CK 6C antibody;CK 6D antibody;CK 6E antibody;CK-6B antibody;CK-6C antibody;CK-6E antibody;Cytokeratin 6a antibody;Cytokeratin 6B antibody;Cytokeratin 6C antibody;Cytokeratin 6D antibody;Cytokeratin 6E antibody;Cytokeratin-6B antibody;Cytokeratin-6C antibody;Cytokeratin-6E antibody;K2C6C_HUMAN antibody;K6a keratin antibody;K6b keratin antibody;K6C antibody;K6c keratin antibody;K6d keratin antibody;K6e keratin antibody;Keratin antibody;Keratin K6h antibody;Keratin type II cytoskeletal 6A antibody;Keratin type II cytoskeletal 6B antibody;Keratin type II cytoskeletal 6C antibody;Keratin type II cytoskeletal 6D antibody;Keratin type II cytoskeletal 6E antibody;Keratin-6C antibody;KRT6A antibody;KRT6B antibody;KRT6C antibody;KRT6D antibody;KRT6E antibody;type II cytoskeletal 6C antibody;Type-II keratin Kb12 antibody

SUBCELLULAR LOCATION

Intermediate filament, Keratin.

FUNCTION

The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin (KRT5) is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.