Mouse monoclonal primary
Cytokeratin 5+6 Mouse Monoclonal Antibody [A2B2] (EM1901-08)
Synthetic peptide within human cytokeratin 5 aa 340-380.
HT-29 cell, human tonsil tissue, human skin tissue, A431.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
Keratin, type II cytoskeletal 6B; Cytokeratin-6B; Keratin-6B; Type-II keratin Kb10; Keratin, type II cytoskeletal 5; 58 kDa cytokeratin; Cytokeratin-5; Keratin-5; Type-II keratin Kb5
Belongs to the intermediate filament family.
Expressed in the corneal epithelium (at protein level).
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.