Recombinant Rabbit monoclonal primary
Cytokeratin 4 Recombinant Rabbit Monoclonal Antibody [SN74-03] (ET1611-71)
A431, SW480, Hela, human tonsil tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
CK 4 antibody; CK-4 antibody; CK4 antibody; CYK4 antibody; Cytokeratin 4 antibody; Cytokeratin-4 antibody; Cytokeratin4 antibody; FLJ31692 antibody; K2C4_HUMAN antibody; K4 antibody; Keratin 4 antibody; Keratin antibody; Keratin type II cytoskeletal 4 antibody; Keratin-4 antibody; Keratin4 antibody; KRT 4 antibody; Krt4 antibody; type II cytoskeletal 4 antibody; Type-II keratin Kb4 antibody
Belongs to the intermediate filament family.
Detected in the suprabasal layer of the stratified epithelium of the esophagus, exocervix, vagina, mouth and lingual mucosa, and in cells and cell clusters in the mucosa and serous gland ducts of the esophageal submucosa (at protein level). Expressed widely in the exocervix and esophageal epithelium, with lowest levels detected in the basal cell layer.
Cell surface, intermediate filament cytoskeleton, nucleus.
Cytokeratins are a subfamily of intermediate filament keratins that are characterized by a remarkable biochemical diversity, which is represented in human epithelial tissues by at least 20 different polypeptides. Cytokeratins range in isoelectric range between 4.9 and 7.8. Cytokeratin 1 has the highest molecular weight, while Cytokeratin 19 has the lowest molecular weight. The cytokeratins are divided into the type I and type II subgroups. Type II family members comprise the basic to neutral members, Cytokeratins 1-8, while the type I group comprises the acidic members, Cytokeratins 9-20. Various epithelia in the human body usually express cytokeratins which are characteristic of the type of epithelium and related to the degree of maturation or differentiation within said epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. Cytokeratin 4 is expressed in differentiated layers of the mucosal and esophageal epithelia along with Cytokeratin 13.