Cytokeratin 4 Recombinant Rabbit Monoclonal Antibody [SN2001] (ET1611-91)

UNIPROT #

P19013

PROTEIN NAME

Cytokeratin 4

SYNONYMS

CK 4 antibody;CK-4 antibody;CK4 antibody;CYK4 antibody;Cytokeratin 4 antibody;Cytokeratin-4 antibody;Cytokeratin4 antibody;FLJ31692 antibody;K2C4_HUMAN antibody;K4 antibody;Keratin 4 antibody;Keratin antibody;Keratin type II cytoskeletal 4 antibody;Keratin-4 antibody;Keratin4 antibody;KRT 4 antibody;Krt4 antibody;type II cytoskeletal 4 antibody;Type-II keratin Kb4 antibody

SEQUENCE SIMILARITIES

Belongs to the intermediate filament family.

TISSUE SPECIFICITY

Detected in the suprabasal layer of the stratified epithelium of the esophagus, exocervix, vagina, mouth and lingual mucosa, and in cells and cell clusters in the mucosa and serous gland ducts of the esophageal submucosa (at protein level). Expressed widely in the exocervix and esophageal epithelium, with lowest levels detected in the basal cell layer.

SUBCELLULAR LOCATION

Cell surface, intermediate filament, nucleus.

FUNCTION

Keratin, type I cytoskeletal 4 also known as cytokeratin-4 (CK-4) or keratin-4 (K4) is a protein that in humans is encoded by the KRT4 gene.Keratin 4 is a type II cytokeratin. It is specifically found in differentiated layers of the mucosal and esophageal epithelia together with keratin 13. Mutations in the genes encoding this protein have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia.