Cytokeratin 17 Rabbit Polyclonal Antibody (ER1803-94)

UNIPROT #

Q04695

PROTEIN NAME

Cytokeratin 17

SYNONYMS

39.1 antibody;CK 17 antibody;CK17 antibody;CK-17 antibody;Cytokeratin-17 antibody;K17 antibody;K1C17_HUMAN antibody;Keratin 17 antibody;keratin 17 epitope S1 antibody;keratin 17 epitope S2 antibody;keratin 17 epitope S4 antibody;Keratin 17, type I antibody;Keratin antibody;Keratin type I cytoskeletal 17 antibody;keratin, type i cytoskeletal 17 [version 1] antibody;Keratin-17 antibody;KRT17 antibody;PC antibody;PC2 antibody;PCHC1 antibody;type I cytoskeletal 17 antibody

SEQUENCE SIMILARITIES

Belongs to the intermediate filament family.

TISSUE SPECIFICITY

Expressed in the outer root sheath and medulla region of hair follicle specifically from eyebrow and beard, digital pulp, nail matrix and nail bed epithelium, mucosal stratified squamous epithelia and in basal cells of oral epithelium, palmoplantar epidermis and sweat and mammary glands. Also expressed in myoepithelium of prostate, basal layer of urinary bladder, cambial cells of sebaceous gland and in exocervix (at protein level).

POST-TRANSLATIONAL MODIFICATION

Phosphorylation at Ser-44 occurs in a growth- and stress-dependent fashion in skin keratinocytes, it has no effect on filament organization.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Cytokeratin 17 is a member of the Cytokeratin subfamily of intermediate filament proteins (IFPs). It is unique in that it is normally expressed in the basal cells of complex epithelia but not in stratified or simple epithelia. Cytokeratin 17 contains 432 amino acids and is expressed in the nail bed, hair follicle, sebaceous glands and other epidermal appendages. Cytokeratin 17 functions to regulate cell growth and size through its interactions with the adaptor protein 14-3-3-sigma to mediate protein synthesis. Mutations in the gene encoding for Cytokeratin 17 lead to depressed protein translation and smaller sized skin keratinocytes, corresponding to decreased Akt/mTOR signaling activity. Cytokeratin 17 may be a useful marker for cervical stem cell identification, squamous cell carcinoma of the larynx, respiratory syncytial virus and transitional cell carcinomas of the human urinary tract.