Cytokeratin 16 Recombinant Rabbit Monoclonal Antibody [SC52-09] (ET1610-17)

UNIPROT #

P08779

PROTEIN NAME

Cytokeratin 16

SYNONYMS

CK 16 antibody;CK-16 antibody;CK16 antibody;Cytokeratin-16 antibody;Cytokeratin16 antibody;FNEPPK antibody;Focal non epidermolytic palmoplantar keratoderma antibody;K 16 antibody;K16 antibody;K1C16_HUMAN antibody;K1CP antibody;Keratin 1 type I antibody;Keratin 16 antibody;Keratin antibody;Keratin type I cytoskeletal 16 antibody;Keratin-16 antibody;Keratin16 antibody;KRT 16 antibody;Krt16 antibody;KRT16A antibody;NEPPK antibody;PC1 antibody;type I cytoskeletal 16 antibody

SEQUENCE SIMILARITIES

Belongs to the intermediate filament family.

TISSUE SPECIFICITY

Expressed in the corneal epithelium (at protein level).

SUBCELLULAR LOCATION

Cytoskeleton, intermediate filament, cytosol, extracellular exosome, nucleus.

FUNCTION

Cytokeratins comprise a diverse group of intermediate filament proteins that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. The cytokeratin proteins play a critical role in differentiation, as well as tissue specialization and function, to maintain the overall structural integrity of epithelial cells. Cytokeratins are also useful markers in identifying the origin of metastatic tumors. Cytokeratin 16 is expressed in benign stratified squamous epithelium and squamous cell carcinoma of the head and neck, as well as luminal cells of mammary gland and sweat ducts. It is absent in noninvasive breast carcinomas and normal breast tissue. Mutations in the Cytokeratin 16 gene cause various diseases, including pachyonychia congenita type 1 (PC1), nonepidermolytic palmoplantar keratoderma (NEPPK) and unilateral palmoplantar verrucous nevus (UPVN).