Cytokeratin 14 Rabbit Polyclonal Antibody (ER1901-08)

UNIPROT #

P02533

PROTEIN NAME

Cytokeratin 14

SYNONYMS

CK 14 antibody;CK-14 antibody;ck14 antibody;Cytokeratin 14 antibody;Cytokeratin-14 antibody;Cytokeratin14 antibody;Dowling Meara antibody;EBS3 antibody;EBS4 antibody;Epidermolysis bullosa simplex antibody;K14 antibody;K1C14_HUMAN antibody;Keratin 14 (epidermolysis bullosa simplex, Dowling-Meara, Koebner) antibody;Keratin 14 antibody;Keratin antibody;Keratin type I cytoskeletal 14 antibody;Keratin, type I cytoskeletal 14 antibody;Keratin-14 antibody;Keratin14 antibody;Koebner antibody;Krt 14 antibody;Krt14 antibody;NFJ antibody;OTTHUMP00000164624 antibody;type I cytoskeletal 14 antibody

SEQUENCE SIMILARITIES

Belongs to the intermediate filament family.

TISSUE SPECIFICITY

Expressed in the corneal epithelium (at protein level). Detected in the basal layer, lowered within the more apically located layers specifically in the stratum spinosum, stratum granulosum but is not detected in stratum corneum. Strongly expressed in the outer root sheath of anagen follicles but not in the germinative matrix, inner root sheath or hair. Found in keratinocytes surrounding the club hair during telogen.

POST-TRANSLATIONAL MODIFICATION

A disulfide bond is formed between rather than within filaments and promotes the formation of a keratin filament cage around the nucleus.; Ubiquitinated by the BCR(KLHL24) E3 ubiquitin ligase complex.

SUBCELLULAR LOCATION

Cytoplasm. Nucleus.

FUNCTION

Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed in pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The a-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins are useful markers of tissue differentiation and, in addition, they aid in the characterization of malignant tumors. In Bowen’s disease, the characteristic malignancy of the epidermis exhibits distinct expression patterns of Cytokeratin 14. The gene encoding human Cytokeratin 14 maps to chromosome 17q12-21. Mutations in this gene lead to epidermolysis bullosa simplex, an inheritied skin disorder characterized by skin blistering due to basal keratinocyte fragility.