Cytokeratin 13 Rabbit Polyclonal Antibody (R1601-8)

UNIPROT #

P13646

PROTEIN NAME

Cytokeratin 13

SYNONYMS

47 kDa cytokeratin antibody;CK-13 antibody;CK13 antibody;Cytokeratin 13 antibody;Cytokeratin-13 antibody;K13 antibody;K1C13_HUMAN antibody;Ka13 antibody;Keratin 13 antibody;Keratin antibody;keratin type I cytoskeletal 13 antibody;Keratin-13 antibody;Krt-1.13 antibody;Krt1-13 antibody;KRT13 antibody;MGC161462 antibody;MGC3781 antibody;type I cytoskeletal 13 antibody;Type I keratin Ka13 antibody;WSN2 antibody

SEQUENCE SIMILARITIES

Belongs to the intermediate filament family.

TISSUE SPECIFICITY

Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta.

POST-TRANSLATIONAL MODIFICATION

O-glycosylated; glycans consist of single N-acetylglucosamine residues.

SUBCELLULAR LOCATION

Cytoskeleton, Nucleus.

FUNCTION

Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. Cytokeratins have been found to be useful markers of tissue differentiation, which is directly applicable to the characterization of malignant tumors. Cytokeratins 10 and 13 are present in the cytoskeletal region of a subset of squamous cell carcinomas. Cytokeratin 13 belongs to the intermediate filament family and is a heterotetramer of two type I acidic and two type II basic keratins. It is generally associated with cytokeratin 4. Defects in the KRT13 gene are a cause of white sponge nevus of cannon (WSN), a rare autosomal dominant disorder which predominantly affects noncornified stratified squamous epithelia and is characterized by the presence of soft, white and spongy plaques in the oral mucosa.