CYR61 / CCN1 Recombinant Rabbit Monoclonal Antibody [PSH09-12] (HA723070)

UNIPROT #

O00622

PROTEIN NAME

CYR61 / CCN1

SYNONYMS

3CH61 antibody;CCN 1 antibody;CCN family member 1 antibody;CCN1 antibody;CYR 61 antibody;Cyr61 antibody;CYR61 protein antibody;CYR61_HUMAN antibody;Cysteine rich angiogenic inducer 61 antibody;Cysteine rich heparin binding protein 61 antibody;Cysteine-rich angiogenic inducer 61 antibody;GIG 1 antibody;GIG1 antibody;IBP-10 antibody;IGF-binding protein 10 antibody;Igfbp 10 antibody;IGFBP-10 antibody;Igfbp10 antibody;Insulin like growth factor binding protein 10 antibody;Insulin-like growth factor-binding protein 10 antibody;Protein CYR61 antibody;Protein GIG1 antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Cysteine-rich angiogenic inducer 61 (CYR61) or CCN family member 1 (CCN1), is a matricellular protein that in humans is encoded by the CYR61 gene. CYR61 is a secreted, extracellular matrix (ECM)-associated signaling protein of the CCN family (CCN intercellular signaling protein). CYR61 is capable of regulating a broad range of cellular activities, including cell adhesion, migration, proliferation, differentiation, apoptosis, and senescence through interaction with cell surface integrin receptors and heparan sulfate proteoglycans. During embryonic development, CYR61 is critical for cardiac septal morphogenesis, blood vessel formation in placenta, and vascular integrity. In adulthood CYR61 plays important roles in inflammation and tissue repair, and is associated with diseases related to chronic inflammation, including rheumatoid arthritis, atherosclerosis, diabetes-related nephropathy and retinopathy, and many different forms of cancers.