CYP2E1 Recombinant Rabbit Monoclonal Antibody [JM10-85] (ET1703-48)
Catalog# ET1703-48
Rabbit Monoclonal to CYP2E1
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WB
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IF-Tissue
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IHC-P
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Human
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Mouse
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Rat
Specifications
Product Type
Recombinant Rabbit monoclonal primary
Product Name
CYP2E1 Recombinant Rabbit Monoclonal Antibody [JM10-85] (ET1703-48)
Immunogen
Synthetic peptide within human cyp2e1 aa 71-114 / 439.
Host
Rabbit
Positive Control
Human liver tissue lysates, Mouse liver tissue lysate, Rat liver tissue lysate, human liver tissue, mouse liver tissue, rat liver tissue.
Conjugation
Unconjugated
Clonality
Monoclonal
Clone Number
JM10-85
RRID
APPLICATION DILUTION
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WB
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1:1,000-1:5,000
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IF-Tissue
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1:50-1:200
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IHC-P
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1:50-1:200
PROPERTIES
Form
Liquid
Storage Condition
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
Storage Buffer
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Protein A affinity purified.
Molecular Weight
Predicted band size: 57 kDa
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
CYP2E1
SYNONYMS
4-nitrophenol 2-hydroxylase antibody;CP2E1_HUMAN antibody;CPE1 antibody;CYP2E antibody;Cyp2e1 antibody;CYPIIE1 antibody;Cytochrome P450 2E1 antibody;Cytochrome P450 isozyme 3A antibody;Cytochrome P450 LM3A antibody;Cytochrome P450, family 2, subfamily e, polypeptide 1 antibody;cytochrome P450, subfamily IIE (ethanol-inducible), polypeptide 1 antibody;Cytochrome P450, subfamily IIE antibody;Cytochrome P450-ALC antibody;Cytochrome P450-J antibody;Cytochrome P450RLM6 antibody;EC 1.14.13.- antibody;EC 1.14.13.n7 antibody;Ethanol-inducible P450 antibody;Flavoprotein-linked monooxygenase antibody;MGC133529 antibody;Microsomal monooxygenase antibody;OTTHUMP00000020813 antibody;OTTHUMP00000046571 antibody;P450 ALC antibody;P450-J antibody;P450C2E antibody;P450J antibody;P450RLM6 antibody;Xenobiotic monooxygenase antibody
SEQUENCE SIMILARITIES
Belongs to the cytochrome P450 family.
SUBCELLULAR LOCATION
Endoplasmic reticulum, Membrane, Microsome, Mitochondrion, Mitochondrion inner membrane.
FUNCTION
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) .Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics (Probable).
CITATIONS
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Lu, S., Zhao, J., Chen, X., Xu, S., Yang, X., Zhang, Y., Ma, Z., Jiang, H., & Zhou, H.
Proton pump inhibitor-induced risk of chronic kidney disease is associated with increase of indoxyl sulfate synthesis via inhibition of CYP2E1 protein degradation
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WB
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Mouse
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Citation
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Jiang Lu,et al
Spatial transcriptomics reveals the transcriptomic signatures in a mouse model of pediatric metabolic dysfunction-associated steatohepatitis
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IHC
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Mouse
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Citation
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