Lane 1: Rat heart
Lane 2: Human liver
Lane 2: Human kidney
Recombinant Rabbit monoclonal primary
CYP27A1 Recombinant Rabbit Monoclonal Antibody [JG40-36] (ET7109-05)
Recombinant protein corresponding to human cyp27a1 300-500aa.
Rat heart tissue, human liver tissue, human kidney tissue, human small intestine tissue, HepG2, LOVO.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A purified.
12-alpha-triol 27-hydroxylase antibody; 5-beta-cholestane-3-alpha antibody; 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 26-hydroxylase antibody; 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 27-hydroxylase antibody; 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase antibody; 7-alpha antibody; Cholestanetriol 26 monooxygenase antibody; CP27 antibody; CP27A_HUMAN antibody; CTX antibody; CYP antibody; CYP27 antibody; CYP27A1 antibody; Cytochrome P 450C27/25 antibody; Cytochrome P-450C27/25 antibody; Cytochrome P450 27 antibody; Cytochrome P450 27 mitochondrial antibody; Cytochrome P450 family 27 subfamily A member 1 antibody; Cytochrome P450 family 27 subfamily A polypeptide 1 antibody; Cytochrome P450 subfamily XXVIIA (steroid 27-hydroxylase cerebrotendinous xanthomatosis) polypeptide 1 antibody; mitochondrial antibody; Sterol 26 hydroxylase antibody; Sterol 26 hydroxylase mitochondrial antibody; Sterol 26-hydroxylase antibody; Sterol 27 hydroxylase antibody; Sterol 27-hydroxylase antibody; Vitamin D(3) 25 hydroxylase antibody; Vitamin D(3) 25-hydroxylase antibody
Belongs to the cytochrome P450 family.
Expressed in the neural retina and underlying retinal pigment epithelium (at protein level). Expressed in the gray and white matter of cerebellum (at protein level).
P450 enzymes constitute a family of monooxygenase enzymes that are involved in the metabolism of a wide array of endo-genous and xenobiotic compounds. P450 enzymes can be classified, based on their sequence similarities, into distinct subfamilies, which include CYP1A and CYP2A. Other P450 family members include CYP19, also designated aromatase (P450arom), which catalyzes the conversion of C19 steroids to estrogens in various tissues, including placenta, gonads, adipose tissue, skin and brain. CYP19 expression is controlled by hormonally regulated promoters in different tissues and increased aromatase activity is associated with familial gynecomastia. Also, a polymorphic allele of CYP19 (repeat (TTTA)12) is present in a majority of breast cancer patients. P450 cholesterol 7a-hydroxylase, CYP7A1, is the rate limiting enzyme of bile acid synthesis in the liver, and its expression is mediated by the bile acid receptor FXR. CYP27A1 catalyzes vitamin D3 25-hydroxylation and is localized to the mitochondria in kidney and liver.