CYP1B1 Rabbit Polyclonal Antibody (HA500494)
Catalog# HA500494
Rabbit Polyclonal to CYP1B1
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WB
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IHC-P
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Human
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Rat
Positive control:
Lane 1: A549 cell lysate
Lane 2: Hela cell lysate
Specifications
Product Type
Rabbit polyclonal primary
Product Name
CYP1B1 Rabbit Polyclonal Antibody (HA500494)
Immunogen
Recombinant protein within human cyp1b1 aa 231-400.
Host
Rabbit
Positive Control
A549 cell lysate, Hela cell lysate, rat skeletal muscle tissue.
Conjugation
Unconjugated
Clonality
Polyclonal
RRID
APPLICATION DILUTION
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WB
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1:500-1:1,000
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IHC-P
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1:50-1:200
PROPERTIES
Form
Liquid
Storage Condition
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20℃ long term.
Storage Buffer
1*TBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Concentration
1ug/ul
Purification
Immunogen affinity purified.
Molecular Weight
Predicted band size: 61 kDa.
Isotype
IgG
TARGET
UNIPROT #
PROTEIN NAME
CYP1B1
SYNONYMS
Aryl hydrocarbon hydroxylase antibody;CP1B antibody;CP1B1_HUMAN antibody;Cyp1b1 antibody;CYPIB1 antibody;Cytochrome P450 1B1 antibody;Cytochrome P450 family 1 subfamily B polypeptide 1 antibody;Cytochrome P450 subfamily I (dioxin inducible) polypeptide 1 (glaucoma 3 primary infantile) antibody;Flavoprotein linked monooxygenase antibody;GLC3A antibody;Microsomal monooxygenase antibody;P4501B1 antibody;Xenobiotic monooxygenase antibody
SUBCELLULAR LOCATION
Mitochondrion, Endoplasmic reticulum membrane, Microsome membrane.
FUNCTION
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid.
CITATIONS
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Hao Lin,et al
The crucial involvement of gamma-Mangostin and CYP1B1 in the mechanism underlying the toxicity caused by cigarette smoke extract: In silico and in vitro insights
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WB
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Human
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Citation
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