Cyclin E2 Mouse Monoclonal Antibody [40-89] (M0407-15)

UNIPROT #

O96020

PROTEIN NAME

Cyclin E2

SYNONYMS

CCN E2 antibody;CCNE 2 antibody;CCNE2 antibody;CCNE2 protein antibody;CYC E2 antibody;CYCE 2 antibody;CYCE2 antibody;CyclinE2 antibody;G1/S specific cyclin E2 antibody

SEQUENCE SIMILARITIES

Belongs to the cyclin family. Cyclin E subfamily.

TISSUE SPECIFICITY

According to PubMed:9858585, highest levels of expression in adult testis, thymus and brain. Lower levels in placenta, spleen and colon. Consistently elevated levels in tumor-derived cells compared to non-transformed proliferating cells. According to PubMed:9840927: low levels in thymus, prostate, brain, skeletal muscle, and kidney. Elevated levels in lung. According to PubMed:9840943 highly expressed in testis, placenta, thymus and brain. In a lesser extent in small intestine and colon.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation by CDK2 triggers its release from CDK2 and degradation via the ubiquitin proteasome pathway.

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Cyclin E2 is a member of the cyclin E family that can associate with and activate Cdk2. It is essential for the control of the cell cycle at the late G1 and early S phase. Cyclin E2 associates with Cdk2 in a functional kinase complex that is inhibited by both p27 (Kip1) and p21 (Cip1). Cyclin E2 is high expressed in adult testis, thymus and brain. Abnormally high levels of cyclin E expression have frequently been observed in human cancers.