Cyclin D1 Rabbit Polyclonal Antibody (0407-27)

UNIPROT #

P24385

PROTEIN NAME

Cyclin D1

SYNONYMS

AI327039 antibody;B cell CLL/lymphoma 1 antibody;B cell leukemia 1 antibody;B cell lymphoma 1 protein antibody;B-cell lymphoma 1 protein antibody;BCL 1 antibody;BCL-1 antibody;BCL-1 oncogene antibody;BCL1 antibody;BCL1 oncogene antibody;ccnd1 antibody;cyclind1 antibody;CCND1/FSTL3 fusion gene, included antibody;CCND1/IGHG1 fusion gene, included antibody;CCND1/IGLC1 fusion gene, included antibody;CCND1/PTH fusion gene, included antibody;CCND1_HUMAN antibody;cD1 antibody;Cyl 1 antibody;D11S287E antibody;G1/S specific cyclin D1 antibody;G1/S-specific cyclin-D1 antibody;Parathyroid adenomatosis 1 antibody;PRAD1 antibody;PRAD1 oncogene antibody;U21B31 antibody

SEQUENCE SIMILARITIES

Belongs to the cyclin family. Cyclin D subfamily.

POST-TRANSLATIONAL MODIFICATION

Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex.; Ubiquitinated, primarily as 'Lys-48'-linked polyubiquitination. Ubiquitinated by a SCF (SKP1-CUL1-F-box protein) ubiquitin-protein ligase complex containing FBXO4 and CRYAB. Following DNA damage it is ubiquitinated by some SCF (SKP1-cullin-F-box) protein ligase complex containing FBXO31. SCF-type ubiquitination is dependent on Thr-286 phosphorylation (By similarity). Ubiquitinated also by UHRF2 apparently in a phosphorylation-independent manner. Ubiquitination leads to its degradation and G1 arrest. Deubiquitinated by USP2; leading to its stabilization.

SUBCELLULAR LOCATION

Nucleus, Cytoplasm, Nucleus membrane.

FUNCTION

Cyclin D1 is a protein that in humans is encoded by the CCND1 gene. The CCND1 gene encodes the cyclin D1 protein. The human CCND1 gene is located on the long arm of chromosome 11 (band 11q13). It is 13,388 base pairs long, and translates into 295 amino acids. Cyclin D1 is expressed in all adult human tissues with the exception of cells derived from bone marrow stem cell lines (both lymphoid and myeloid). The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDKs (Cyclin-dependent kinase). Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. Micrograph of cyclin D1 staining in a mantle cell lymphoma. Immunohistochemical staining of cyclin D1 antibodies is used to diagnose mantle cell lymphoma. Cyclin D1 has been found to be overexpressed in breast carcinoma. Its potential use as a biomarker was suggested.