Cyclin B2 Recombinant Rabbit Monoclonal Antibody [SD2045] (ET1612-21)

UNIPROT #

O95067

PROTEIN NAME

Cyclin B2

SYNONYMS

ccnb2 antibody;CCNB2_HUMAN antibody;CycB2 antibody;Cyclin B2 antibody;G2 mitotic specific cyclin B2 antibody;G2/mitotic specific cyclin B2 antibody;G2/mitotic-specific cyclin-B2 antibody;HsT17299 antibody;MGC108931 antibody;MGC140694 antibody

SEQUENCE SIMILARITIES

Belongs to the cyclin family. Cyclin AB subfamily.

DEVELOPMENTAL STAGE

Accumulates steadily during G2 and is abruptly destroyed at mitosis.

SUBCELLULAR LOCATION

Centrosome, microtubule cytoskeleton, cytosol, nucleus, cyclin-dependent protein kinase holoenzyme complex, cytoplasm, host cell nucleus, membrane.

FUNCTION

In eukaryotic cells, mitosis is initiated following the activation of a protein kinase known variously as maturation-promoting factor, M-phase specific histone kinase or M-phase kinase. This protein kinase is composed of a catalytic subunit (Cdc2), a regulatory subunit (cyclin B) and a low molecular weight subunit (p13-Suc 1). The Cdc/cyclin enzyme is subject to multiple levels of control of which the regulation of the catalytic subunit by tyrosine phosphorylation is the best understood. Tyrosine phosphorylation inhibits the Cdc2/cyclin B enzyme and tyrosine dephosphorylation, occurring at the onset of mitosis, directly activates the pre-MPF complex . Evidence has established that B-type cyclins not only act on M-phase regulatory subunits of the Cdc2 protein kinase, but also activate the Cdc25A and Cdc25B endogenous tyrosine phosphatase, of which Cdc2 is the physiological substrate. The two B-type cyclins, cyclin B1 and cyclin B2, have been shown to have distinct tissue distributions.